For backup, it is recommended using DriveHQ Online Backup 4.0 client software, which supports filtering of files and folders. Also Online Backup is safer than FileManager for backup purpose:

(1) When you delete a file on your local PC, Online Backup doesn't automatically delete the file on server. You can manually click on the "Delete un-used files on server" button (in the Edit Task screen) to delete the files.

(2) Online Backup can keep multiple versions of a file; in case you accidentally changed some files, you might be able to restore an older version.

(3) Online Backup can run in the service mode; so it can protect your data even if nobody is logged on the PC.

Basically, if you want automatic backup with little human interaction, please use Online Backup; if you want to manually copy / paste / drag files; if you want to share or synchronize files with other people, then use FileManager. Please note Folder Synchronization is not designed for backup. If you delete a file on local, it will also delete the file on server.